Buy Tegopen Online

Flucloxacillin is a so-called narrow spectrum antibiotic. Unlike broad spectrum antibiotics, it only works against a small number of pathogens. Tegopen belongs to the pharmacological group of penicillins and more specifically to isoxazolylpenicillins. The drug is mainly used to treat infectious diseases caused by Staphylococcus aureus.

What is Tegopen?

Flucloxacillin is a so-called narrow spectrum antibiotic. It is used for infectious diseases caused by Staphylococcus aureus.

The active ingredient Tegopen is an acid-stable substance which passes into the stomach without alteration. The half-life of the substance is on average about 45 minutes. Basically, the drug is easily compatible with the tissues and, for example, also passes through the placental barrier. In addition, the active ingredient is excreted in breast milk, which should be observed urgently as part of therapy that takes place during pregnancy.

The active substance flucloxacillin is largely excreted via the kidneys. To a small extent, excretion also occurs via bile.

In principle, Tegopen is a penicillinase resistant antibiotic. It was mainly developed for the treatment of staphylococci which produce β-lactamases. For this reason, the substance is sometimes called staphylococcal penicillin.

In addition, the drug flucloxacillin belongs to the group of isoxazolyl antibiotics. For example, the active ingredient cloxacillin also belongs to this category. On this basis, however, there are no medicinal substances approved for humans in Germany. The substances oxacillin and dicloxacillin also belong to the group of isoxazolyl antibiotics.

Cloxacillin is on the WHO essential medicines list. According to the World Health Organization, it is possible to replace this substance with active substances from the same category of drugs. In Germany, the drugs oxacillin or Tegopen are used for this purpose.

There is also a drug resistant to penicillinase called methicillin. However, this is generally only used for resistance testing by MRSE and MRSA. The corresponding germs cannot be treated with the active ingredient flucloxacillin.

Pharmacological effects

The pharmacological preparation of Tegopen is mainly characterized by its bacteriostatic and bactericidal effects. The drug has an effect against Gram-positive germs, which include, for example, streptococci or staphylococci.

Unlike many other types of penicillins, such as amoxicillin, the drug flucloxacillin is resistant to β-lactamases. This effect is due to the fact that the substance inhibits the synthesis of the bacterial cell wall by altering the transpeptidases. These are jointly responsible for the formation of the peptidoglycan. The structure of penicillin is modified by Tegopen which inhibits transpeptidation on the strands of murine inside the cell walls of bacteria. As a result, the so-called penicillinase loses its effect.

In drugs and medical preparations, the substance flucloxacillin is present in the form of the sodium salt and more specifically Tegopen sodium. It is a white powder with a crystalline appearance. The powder also has hygroscopic properties and dissolves easily in water.

The term flucloxacillin is an abbreviation and means the substance fluor-chloro-oxacillin. The drug Cloxacillin is also available on the market in Switzerland. It is chlorine oxacillin, which does not contain fluorine. In Switzerland, however, this medicine is used exclusively in veterinary medicine and is not intended for the therapy of people.

Medical application and use

Tegopen is used for a variety of diseases. The main indication is usually infectious diseases caused by penicillinase-forming staphylococci. These include, for example, infections that affect the skin or mucous membranes as well as those that affect the airways and bones.

Basically, strains of staphylococci that are sensitive to penicillin G react weakly to the active ingredient flucloxacillin. The substance is also less effective than penicillin G against other Gram-positive pathogens. In the majority of cases, Tegopen is administered intravenously.

Flucloxacillin is suitable for the treatment of infectious diseases caused by a special type of staphylococcus. These are, for example, Staphylococcus aureus and Staphylococcus epidermidis. The pathogens Klebsiella pneumoniae, Streptococcus pyogenes, various types of Neisseria and Bacillus anthracis also belong to this category.

For example, the active ingredient Tegopen is also used for infections in soft tissue, for example in the context of abscesses or boils. The drug can also be used to treat paronychia and pyoderma. Flucloxacillin is also effective against certain infections of the bone marrow.

Here you will find your medication

Risks and side effects

During treatment with the active ingredient Tegopen, indigestion and rashes often occur. Liver disease associated with biliary stasis occurs less frequently.

Flucloxacillin should not be administered in case of intolerance to the active substance or to other penicillins. Even in case of severe liver dysfunction, it is advisable to dispense with the active ingredient. Caution should also be exercised in bronchial asthma. In this case, it is advisable to prescribe alternatives.