Buy Duricef Online

Pharmacotherapeutic group

Antimicrobial agents for systemic use. Cephalosporins.

Drug action

Pharmacodynamics Cefadroxil is a semi-synthetic antibiotic from the cephalosporin series. It has a bactericidal effect. The mechanism of action associated with impaired synthesis of the components of the bacterial cell membrane. Beta-hemolytic streptococci, pneumococci and staphylococci (coagulase positive and coagulase negative, as well as penicillinase producing strains) are sensitive to cefadroxil.

Pharmacokinetics After oral administration, cefadroxil is almost completely absorbed in the upper segment of the small intestine. The maximum concentration in the blood plasma is observed after 1 to 2 hours. The simultaneous intake of food practically does not affect absorption. Compared to other oral cephalosporins, cefadroxil is eliminated from the body much more slowly, so the interval between doses can be 12 to 24 hours. 15 to 20% of cefadroxil binds to plasma proteins. Clinically significant concentrations are determined in many tissues, particularly in the tonsils, tissues and fluids of the respiratory tract, in fluids of the middle ear, eyes, as well as in the skin, muscle tissue, bones and joints, liver and bile, in urine, prostate, and female genitals.

The concentration of cefadroxil in the blood of the fetus and amniotic fluid accounts for about one third of the concentration of the drug in the mother's blood serum. Duricef in small amounts is found in breast milk. About 90% of cefadroxil is excreted unchanged in the urine. Excretion is delayed in patients with renal impairment.

Directions for use

Infections caused by microorganisms sensitive to cefadroxil, namely: chronic otitis media and sinusitis, pharyngitis, tonsillitis, lower respiratory tract infections (acute and chronic bronchitis, pneumonia), urinary tract infections (complicated and uncomplicated), infections skin and soft tissue, bone and joint infections.

Method of use and dose

The capsules are taken orally with enough water, regardless of the meal. The average dose for children with normal kidney function is 25 to 50 mg / kg of body weight per day for 1 or 2 doses with an interval of 12 hours. If necessary, the daily dose can be increased to 100 mg / kg of body weight. Children under 5 years of age are recommended to use cefadroxil in syrup form, and from 5 years can be used in the form of capsules. Children 9 to 12 years old (with a body weight of 30 to 40 kg) 1 g per day for 1 or 2 doses. In severe infections, the dose can be increased by 2 times. Adults and adolescents weighing more than 40 kg with normal renal function are prescribed 1 to 2 g per day for 1 to 2 doses; in severe infections, the dose may be doubled. The duration of treatment is 7-10 days.

Treatment should be continued for 2 to 3 days after the disappearance of acute clinical symptoms. For infections caused by Streptococcus ryogenes, treatment should continue for at least 10 days (children are prescribed 30 mg / kg per day for 1 to 2 doses, adults 1 g / day for 1 to 2 doses). In case of complicated urinary tract infections, adults are given 1 g twice a day for 7-10 days. For infections of the musculoskeletal system, children are prescribed 50 mg / kg of body weight per day for 2 to 4 doses at 6 to 12 hour intervals, for adults 1 g for 4 doses per day at 6 hours d '' interval for 3 to 5 weeks depending on the clinical picture).

In case of chronic renal failure (depending on the clearance of creatinine), to avoid accumulation of cefadroxil, you should increase the duration of the intervals between doses of the drug. With creatinine clearance:

• 40 - 80 mg /min. - 12 hours between doses;
• 20 - 40 ml / min. - 24 hours;
• less than 20 ml / min.
• 48 hours Hemodialysis patients receive half the daily dose, which is administered in 48 hours. before dialysis and the other half after dialysis. The next half of the daily dose during dialysis 2-3 times a week is prescribed for 48 hours. before the subsequent dialysis procedure.

Side effect

Most often, a side effect of the gastrointestinal tract is observed (nausea, vomiting, diarrhea, abdominal pain), allergic rashes are sometimes possible, very rarely glossitis, dizziness, insomnia, anaphylactic shock. In some cases, there is an increase in opportunistic microorganisms (fungi), which can lead to vaginal yeast infection, candidiasis stomatitis, etc.

Cons-indications

Hypersensitivity to cephalosporins. In case of hypersensitivity to penicillins, there is a potential for cross allergy. Pregnancy, lactation period.

Overdose

Symptoms of an overdose: nausea, hallucinations, hyperreflexia, extrapyramidal disorders, blurred consciousness, coma, impaired renal function. First aid when taking a toxic dose: gastric lavage, if necessary - hemodialysis. Monitoring, if necessary - correction of the electrolytic state of water, monitoring of renal function.

Features of use

A cross allergy to penicillins is possible (5 to 10% of cases). In patients with renal impairment, the intervals between doses of Duricef should be increased. With prolonged use of Cefadroxil, the composition of the blood and the functional state of the liver and kidneys should be monitored. In case of allergic reactions and diarrhea, treatment with Duricef should be stopped. If pseudomembranous colitis caused by antibiotics is suspected, treatment with vancomycin should be started. Antiperistaltic drugs are contraindicated.

With long-term treatment, possible hypovitaminosis K (hemorrhage), hypovitaminosis B (stomatitis, glossitis, neuritis, anorexia, etc.) and a false positive direct Coombs test: it should be borne in mind that positive results of the Coombs test are associated with the use of cefadroxil. This also applies to newborns whose mothers have been treated with cephalosporins before delivery.

In the treatment of nursing mothers, milk should be expressed and not used. You can breastfeed 2 days after the end of treatment.

Interaction with medication

The use of cefadroxil in combination with aminoglycoside antibiotics, polymyxin B, colistin or high doses of diuretics which affect reabsorption in the loop of Henle is undesirable, as this combination contributes to potentiating the nephrotoxic effect. With prolonged use of anticoagulants or platelet aggregation inhibitors, the risk of bleeding complications increases. Cefadroxil may decrease the effectiveness of oral contraceptives.

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