Buy Maxaquin Online

Pharmacological action

Antimicrobial agent from the fluoroquinolone group. It has a bactericidal effect. It inhibits the activity of DNA gyrase, an enzyme involved in the transcription and replication of bacterial DNA.

Very active against aerobic Gram negative bacteria: Escherichia coli, Salmonella spp., Citrobacter diversus, Enterobacter cloacae, Haemophilus influenzae, Klebsiella pneumoniae, Proteus vulgaris, Morganella morganii, Legionella pneumophila, Neisseria gonorrrhoeae catherais neisseria merisseriaisser neisseria merisseriaisseriaisser.

Proteus mirabilis, Proteus stuartii, Providencia rettgeri, Pseudomonas aeruginosa, Serratia liquefaciens, Serratia agglomerans, Haemophilus parainfluenzae, Providencia alcalifaciens, Aeromonas hydrophila, Chlambacerum tuberculosis, Chlamphobiacephalius Staphylococcus epidermid.

Streptococcus spp., Pseudomonas cepacia, Ureaplasma urealyticum, Mycoplasma hominis and anaerobic bacteria are resistant to lomefloxacin.

Lomefloxacin has anti-tuberculosis activity, acting on both Mycobacterium tuberculosis extra and intracellular.

Pharmacokinetics

After oral administration, lomefloxacin is almost completely absorbed from the digestive tract, the absorption is 95 to 98%. Binding to plasma proteins 10%.

It is widely distributed in the body. The concentrations in tissues and body fluids are generally 2 to 7 times higher than in plasma, especially in prostate tissue and urine.

T1 / 2 of lomefloxacin is 7 to 9 hours and approximately 70 to 80% is excreted unchanged in the urine for 24 hours.

In patients with renal impairment, T1 / 2 is significantly increased.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to lomefloxacin, including urinary tract infections (cystitis, pyelonephritis), prostatitis; lower respiratory tract infections; acute and chronic purulent infections of soft tissue, infected wounds, osteomyelitis; cholera (severe form); tuberculosis (as part of combination therapy); acute and chronic gonorrhea; acute and recurrent chlamydia.

Prevention of urinary tract infections before and after transurethral surgery.

For topical use in ophthalmology: bacterial infections of the anterior eye (including conjunctivitis, blepharitis, blepharoconjunctivitis).

Dosage schedule

When taken orally, the daily dose is 400 to 800 mg, the frequency of administration and the duration of treatment are defined individually. Locally in ophthalmology apply 2 to 3 times / day for 7 to 10 days. At the start of treatment, more frequent use is recommended.

Side effect

• From the digestive system: nausea, vomiting, diarrhea.
• From the central nervous system: headaches, anxiety, sleep disturbances.
• Dermatological reactions: in some cases - photosensitization, rash.
• Effects due to chemotherapeutic action: with prolonged use, candidiasis is possible.
• Local reactions: rarely - burning sensation that occurs immediately after instillation.

Cons-indications

Pregnancy, breast-feeding (breast-feeding), children and adolescents under 15 years of age, hypersensitivity to quinolone derivatives.

Pregnancy and breast feeding

Maxaquin is contraindicated during pregnancy and breastfeeding (breastfeeding).

Use in renal failure

In case of renal failure, a correction of the dosage regimen is necessary depending on the QC values.

Use in children

Contraindicated in children and adolescents under 15 years of age.

Special instructions

Caution should be exercised in severe cerebral atherosclerosis, epilepsy and other diseases of the central nervous system.

In case of renal failure, a correction of the dosage regimen is necessary depending on the QC values.

During the treatment period, prolonged exposure to the sun and the use of artificial ultraviolet light should be avoided.

Do not use locally together with antibiotics for use in ophthalmology, acting bacteriostatically.

Vitamins with mineral supplements should be used 2 hours before or 2 hours after using lomefloxacin.

It should not be forgotten that with the use of fluoroquinolones, peripheral neuropathy is possible; an adverse effect on the tendons (including ruptures) during and after treatment; accumulation of caffeine, causing stimulation of the central nervous system; pseudomembranous colitis; prolongation of the QTc interval (risk of developing ventricular arrhythmias, in particular pirouette type).

Drug interaction

With the simultaneous use of antacids and sucralfate, chelate complexes are formed, which reduces the bioavailability of lomefloxacin (antacids and sucralfate should not be taken for 4 hours before and 2 hours after taking lomefloxacin).

In the case of simultaneous use with rifampicin (in patients with tuberculosis), an antagonism of action is observed.

With the simultaneous use of lomefloxacin, it practically does not inhibit the metabolism of theophylline.

With the simultaneous use of lomefloxacin and caffeine in large doses, an increase in T1 / 2 of the latter is possible.

Drugs that block tubular secretion slow the excretion of lomefloxacin. The simultaneous use of lomefloxacin increases the activity of oral anticoagulants and increases the toxicity of NSAIDs.

With the simultaneous use of fluoroquinolones with NSAIDs, seizures are possible.

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7. Taking lomefloxacin increases the risk of developing peripheral neuropathy
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