Buy Cephalexin Online

Directions for use

Infections caused by drug-sensitive microorganisms:

• otolaryngological infections (pharyngitis, otitis media, sinusitis, tonsillitis);
• respiratory tract infections (bronchitis, pneumonia, empyema and lung abscess);
• infections of the genitourinary system (pyelonephritis, cystitis, urethritis, prostatitis, epididymitis, endometritis, gonorrhea, vulvovaginitis);
• skin and soft tissue infections (furunculosis, abscess, phlegmon, pyoderma, lymphadenitis, lymphangitis);
• bone and joint infections (osteomyelitis).

Special instructions:

• culture and sensitivity tests should be determined before and during treatment. If necessary, kidney function should be monitored.

Dosage schedule

The dosing schedule for cephalexin is defined individually, taking into account the severity of the course, the location of the infection and the sensitivity of the pathogen.

The drug is prescribed orally, 30-40 minutes before a meal, the capsules are taken without chewing, drinking 150-200 ml of water.

Adults and children over 12 years of age are prescribed a dose of 250 mg 4 times / day (every 6 hours) or 500 mg 2 times / day (every 12 hours). The daily dose is 1000 mg, in severe cases of infection the daily dose can be increased to 4000 mg.

In patients with renal impairment (with a creatinine clearance of 10 ml / min or less), the maximum daily dose should not exceed 1500 mg.

Elderly patients:

• Pharmacokinetic data show that there is no need to adjust the dosage of the drug in elderly patients, however, age-related changes in renal function should be taken into account. In case of significant violation of this, the dose should be reduced and careful monitoring of renal function during treatment should be carried out.

The duration of treatment depends on the nature and severity of the pathological process and is determined by the data from bacteriological studies. As a rule, the duration of treatment is 7 to 14 days, but for serious infectious diseases, longer treatment may be necessary. In most infectious diseases, treatment continues for at least 48 to 72 hours after the symptoms of the disease have disappeared and / or according to the results of bacteriological analysis. For infections caused by group A beta hemolytic streptococcus, the minimum course of treatment is 10 days.

Side effects

From the digestive system:

• pain in the abdomen, dry mouth, decreased appetite, nausea, vomiting, dyspepsia, gastritis, diarrhea, toxic hepatitis, cholestatic jaundice, candidomycosis of the intestine and oral cavity;
• rarely - bites, including pseudomembranous enterocolitis.

From the hemopoietic system:

• neutropenia, leukopenia, thrombocytopenia / thrombocytosis, pancytopenia, agranulocytosis, lymphopenia, hemolytic anemia, aplastic anemia, eosinophilia, bleeding.

Allergic reactions:

• hives, angioedema, erythematous rashes, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome), anaphylactic shock, arthralia, arthritis, itching of the genitals and anus, fever.

From the nervous system:

• dizziness, weakness, headache, restlessness, hallucinations, cramps.

From the genitourinary system:

• genital candidiasis, vaginitis, interstitial nephritis, possible manifestations of nephrotoxicity in patients with renal impairment.

Laboratory indicators:

• transient increase in liver transaminases, alkaline phosphatase, bilirubin, LDH, urea, creatinine in blood serum;
• increased prothrombin time.

Cons-indications

• a history of allergic reactions (anaphylaxis) to penicillins, penicillin derivatives, penicylamine or cephalosporins;
• gastrointestinal diseases, especially non-specific ulcerative colitis associated with the use of antibiotics (cephalosporin can cause pseudomembrane colitis);
• serious violations of the liver and kidneys;
• children under 12.

Pregnancy and breast feeding

Perhaps if the expected effect of the therapy exceeds the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Use for impaired liver function

Use with caution in severe liver failure.

Use in renal failure

Use with caution in severe renal impairment.

Use in elderly patients

Pharmacokinetic data show that there is no need to adjust the dosage of the drug in elderly patients, however, age-related changes in renal function should be taken into account. In case of significant violation of this, the dose should be reduced and careful monitoring of renal function during treatment should be carried out.

Use in children

Contraindicated in children under 12 years of age.

Special instructions

The use of cephalexin is only possible as directed by a doctor.

Before prescribing cephalexin, a complete examination of the patient is necessary, taking into account possible hypersensitivity reactions to cephalosporins and penicillins.

It is used with caution in severe renal and / or hepatic insufficiency, history of colitis.

During treatment you cannot drink alcohol and drugs containing alcohol. When prescribing almost all broad-spectrum antibiotics (including macrolides, semi-synthetic penicillins and cephalosporins), cases of pseudomembrane colitis are possible, therefore this diagnosis should be considered in patients with diarrhea developed after using antibiotics. Such colitis can occur in mild and life-threatening forms. Mild forms of pseudomembrane colitis usually disappear after stopping the medication. Medium and severe forms require rectosigmoscopy, as well as bacteriological analysis, the introduction of fluids, electrolytes and protein supplements.

If, after stopping the drug, the patient's condition has not improved, or in cases of severe colitis, vancomycin is administered orally. Other causes of colitis are excluded.

When taking cephalexin, a false positive reaction to sugar in the urine is possible with the use of the reagents Benedict and Feling, as well as a positive direct Coombs reaction.

Influence on the ability to drive vehicles or other mechanisms The use of cephalexin does not affect the ability to drive and work with other mechanisms.

Overdose

• nausea, vomiting, discomfort in the epigastric region, diarrhea and hematuria. If other symptoms are observed, they appear to be secondary to the underlying condition.

Treatment:

• symptomatic therapy.

Drug interaction

The wide spectrum of action of cephalexin allows the drug to be used both for monotherapy of infections and for combined treatment in combination with other drugs, including antibiotics.

However, it should be borne in mind that with the simultaneous administration of cephalexin with monoglycoside antibiotics, loop diuretics (ethacrylic acid, furosemide), polymyxins, the risk of nephrotoxicity increases. The combined use of cephalexin and erythromycin reduces the effectiveness of both drugs.

With the simultaneous use of cephalexin and metformin, an adjustment of the metformin dose may be necessary (with the combined use of drugs, the concentration of metformin in the blood plasma increases). Probenecid, phenylbutazone inhibits the renal excretion of cephalexin.

Nonsteroidal anti-inflammatory drugs (indomethacin, acetylsalicylic acid) slow the excretion of cephalexin.

The simultaneous use of cephalexin with indirect anticoagulants can lead to an increase in prothrombin time.

Cephalexin enhances the action of antithrombotic agents and vitamin K antagonists. When administered concomitantly with oral coagulants, the possibility of prolonging the prothrombin time should be considered.

Pharmacy vacation conditions

The drug is a prescription.