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Article about Cipro

Ciprofloxacin is a broad-spectrum antibiotic. The active ingredient is from the group of fluoroquinolones. The pharmaceutical company Bayer developed Cipro in 1981, the patent was granted in 1983.

What is Cipro?

Ciprofloxacin is a broad spectrum antibiotic.

Cipro is an active ingredient used against various diseases. It belongs to the group of so-called synthetic antibiotics. The active ingredient has an extremely broad spectrum of activity and is classified as one of the fluoroquinolones.

Antibiotics from the fluoroquinolone group have the property of inhibiting the so-called gyrase in bacteria. This affects bacteria in the replication of their DNA because cell division slows down. As a result, bacteria cannot multiply. Thus, ciprofloxacin has a bactericidal effect, which is mainly directed against Gram-negative germs.

Pharmacological effects

The antibiotic Cipro influences both gyrase and DNA topoisomerase type IV, which reduces DNA synthesis performance and the ability of bacterial cell division. There are also other active mechanisms under discussion that have not yet been the subject of in-depth research.

Ciprofloxacin has a secondary bactericidal effect. This means that the effect of the substance improves, the faster the bacteria multiply. If protein biosynthesis or RNA synthesis by chloramphenicol, macrolides or rifampicin is reduced at the same time, it reduces the effectiveness of the antibiotic Cipro.

The substance is characterized by a very broad spectrum of activity. Like other types of fluoroquinolones, ciprofloxacin is particularly effective against Gram-negative pathogens. However, Cipro also has an effect against germs in the gram-positive range. In addition, intracellular pathogens are combated.

To be able to exert its effect, the correct dosage of the substance according to the disease to be treated is essential. The dose and duration of use varies depending on the type of infection. In most cases, ciprofloxacin is given twice a day. The preferred form of consumption is generally the tablet.

For certain diseases, a single dose of Cipro in an amount of 500 milligrams is sufficient. This is the case, for example, with gonorrhea (gonorrhea). There is also the possibility of intravenous administration. Local application of ciprofloxacin in the form of eye or ear drops is also possible.

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Medical application and use

The administration of Cipro is indicated for bacterial infections, the pathogens of which are sensitive to the substance. These include, for example, respiratory tract infections caused by Haemophilus influenzae or Moraxella catarrhalis.

Ciprofloxacin can be used for urinary tract infections caused by Proteus, Escherichia coli or Klebsiella. Cipro can also be used for gastrointestinal infections caused by Shigella, Salmonella, typhoid or Campylobacter.

In addition, the antibiotic can be used against the problematic pathogen Pseudomonas aeruginosa. This causes diseases such as cystic fibrosis, malignant otitis externa and osteomyelitis. In addition, prophylactic use of the active ingredient is possible in relatives of a patient with meningococcal meningitis.

In principle, the antibiotic should only be used for respiratory infections after careful consideration, because it does not act sufficiently against the responsible germs, pneumococci. Ciprofloxacin can also be used to treat bile duct infections and anthrax.

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  • Risks and side effects

    Cipro is associated with a variety of possible side effects, which can sometimes be very serious. The most common side effects are nausea, rash, and diarrhea. Use during pregnancy and lactation is not recommended and children should not be given ciprofloxacin. Animal studies in young dogs have shown that Cipro affects the growth of cartilage.

    Other possible side effects include liver toxicity and neurotoxicity of the active ingredient as well as allergic reactions. Observations indicate a link with Red-Man syndrome. Since ciprofloxacin can lower the seizure threshold, people with seizures should avoid the antibiotic if possible or take it only under strict observation.

    Many of the described side effects of Cipro are related to tendons. This can cause swelling, pain, inflammation, and tears in the tendons. The back of the ankle can also be affected.

    Such side effects can occur in people of all ages. Swelling and pain are the most common on the Achilles tendon. Tendon ruptures are still possible months after treatment with ciprofloxacin. The likelihood of tendon damage also increases in patients over the age of 60. Observations indicate that certain parts of the active ingredient can reduce the resistance of tendons.

    In rare cases, psychotic disorders up to suicidal tendencies have been described while taking Cipro. Patients with seizures or an irregular heartbeat should avoid foods and medicines containing caffeine, as the effects of caffeine are increased. Any side effect that occurs should always be reported to the attending physician.

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