Buy Macrobid Online

A Nitrofurantoin is an antibiotic. The drug is used to treat bacterial infections of the urinary tract.

What is Macrobid?

Macrobid is a synthetic derivative of nitrofuran which is classified as a chemotherapy drug. It is suitable for the treatment of bacterial diseases of the urinary tract and is the first choice since 2011.

Nitrofurantoin requires a prescription and can only be purchased with a prescription.

The search for a chemically manufactured nitrofuran antibiotic began in the 1940s. As a result, Macrobid was finally discovered. Beginning in the 1950s, the antibiotic was used to fight urinary tract infections. Generics containing nitrofurantoin are also used in Germany.

Pharmacological effects

Macrobid is one of the so-called prodrugs. This means that its conversion to its active form takes place only in the urinary tract. Bacterial enzymes are responsible for this transformation. They become active after the active substance has been absorbed into the blood.

The antibiotic has the ability to penetrate the bacteria that trigger urinary tract infection. Within bacterial cells, nitrofurantoin is converted to a therapeutically active form (via nitroreductases). By attacking the genetic makeup of bacteria, germs can ultimately be made harmless. In addition, the metabolic enzymes vital to the bacterial cells are deliberately destroyed.

The active form of Macrobid has different points of attack on bacterial cells. In this way, resistance to the antibiotic is very rare. Nitrofurantoin also has the advantage that the drug not only inhibits the growth of bacteria, but selectively kills germs. Therefore, Macrobid is considered a bactericidal antibiotic.

The chemotherapeutic agent acts against bacteria such as staphylococci, enterococci, Escherichia coli, Enterobacter and tights. No effect due to natural resistance, but nitrofurantoin does not work with the bacteria Proteus, Pseudomonas aeruginosa, Morganella morganii and Provicencia.

Macrobid reaches its highest level in the urine approximately 4 to 5 hours after administration. About 50% of the antibiotic is converted to ineffective metabolic products, which are also excreted in the urine. A harmless side effect is brown discoloration of the urine.

Medical application and use

Nitrofurantoin is used for acute uncomplicated inflammation of the bladder. Uncomplicated infections are diseases without fever, discharge, vaginal itching, back or kidney pain, and nausea and vomiting.

Macrobid is also suitable for prevention if the urinary tract narrows or if urinary tract infections recur. If it is an acute urinary tract infection, the duration of treatment is usually 5 to 7 days. In the case of prevention, therapy can last up to six months. However, the dosage is lower.

Nitrofurantoin is taken in three to four individual doses in the form of 100 milligram capsules. If prolonged-release capsules are administered with delayed release of the active ingredient, the dose is two to three capsules. The medication is taken with a little water every six to eight hours as part of a meal.

In acute infections, Macrobid should be administered for as long as the doctor has prescribed. This also applies if symptoms improve. If nitrofurantoin is given as a preventative, the patient usually takes one tablet before bed, after the last urination.

Here you will find your medication

Risks and side effects

As with other antibiotics, taking Macrobid can have unwanted side effects. About ten percent of all patients suffer from allergic reactions such as rash, redness, itching and swelling, impaired coordination of movement, tremors in the eyes and dizziness. The attending physician must be promptly informed of allergic reactions.

About one in ten in a hundred patients also suffer from side effects such as loss of appetite, cough, chest pain, nausea, vomiting and headache. Medicinal fever, inflammation of the parotids, anemia, inflammation of the liver or liver damage occur very rarely.

If nitrofurantoin is taken for more than a year, pneumonia often occurs in older women. In addition, lung tissue is converted to connective tissue, which can have fatal consequences. Long-term treatment with Macrobid is therefore not recommended by the BfArM (Federal Institute for Drugs and Medical Devices).

Nitrofurantoin should not be used if the patient has inflamed nerves, urinary retention or urinary runoff, glucose-6-phosphate dehydrogenase deficiency, or kidney disease. In the event of allergies, pulmonary fibrosis, bronchial asthma or inflammation of the liver, a coherent evaluation between risk and benefit of a dose of Macrobid must be carried out.

During pregnancy, nitrofurantoin can only be used in the first six months if the doctor has carefully weighed the risks and benefits. In the final phase of pregnancy, the antibiotic should generally not be taken. For example, Macrobid can cause anemia in babies. If the mother is taking nitrofurantoin, the child should not be breastfed while breastfeeding if he is suspected of being deficient in glucose-6-phosphate dehydrogenase.

The positive effect of Macrobid may be impaired by interactions when taking other medicines at the same time. These include the antibiotic nalidixic acid, the stomach acid preservatives containing magnesium, the gastric remedy propantheline bromide as well as the preparations of gout sulfinpyrazone and probenecid. These reduce the effect of nitrofurantoin and increase unwanted side effects.

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