Buy Chloromycetin Online

Chloramphenicol is a broad-spectrum antibiotic which, due to possible serious side effects, is only used as a reserve antibiotic in severe, if not uncontrollable, bacterial infections. It can trigger a life-threatening aplastic anemia.

What is Chloromycetin?

Chloramphenicol is a broad spectrum antibiotic which, due to the possibility of aplastic anemia as a side effect, is only used as a reserve antibiotic. It was first obtained in 1947 from the bacteria streptomyces venezuelae. Today, it is entirely synthetic.

Treatment with Chloromycetin can lead to life-threatening aplastic anemia. For this reason, it is not widely used, but is only used as a reserve antibiotic in bacterial infections that cannot be controlled otherwise. In principle, however, it has a broad spectrum of activity against gram-positive and gram-negative bacteria.

Topical use is not recommended as systemic side effects are possible; however, chloramphenicol is still approved in skin care products, eye and ear drops and eye ointments. However, it should be noted that the occurrence of systemic side effects with topical treatment is very low. An individual assessment must therefore always take place. The risks of topical use of Chloromycetin are controversial among experts.

In veterinary medicine, chloramphenicol is used against chytridiomycosis, a fungal disease in amphibians. It is therefore also effective against the chytrid fungus (a fungus).

Pharmacological effects

Chloromycetin prevents the translation of mRNA into amino acids. It is therefore a so-called translation inhibitor. This leads to the inhibition of the accumulation of bacterial proteins and therefore also to the growth and multiplication of bacteria. Chloramphenicol is therefore a bacteriostatic antibiotic.

It is easy to move through the tissues, also in the placenta (breast cake) and breast milk. With oral administration, the bioavailability is 80%, with an intramuscular injection of 70%. Binding to plasma proteins is between 50 and 60%, the plasma half-life is between 1.5 and 3.5 hours. In the event of renal and hepatic dysfunction, the plasma half-life increases, which must be taken into account in the dosage. The metabolism is hepatic, almost exclusively by glucuronidation. Elimination then takes place via the kidneys.

Medical application and use

Due to the unfavorable side effect profile, Chloromycetin is only used as a back-up antibiotic if other treatment options are not available or have failed. The main indications are serious bacterial infections which cannot be controlled otherwise. These indications for chloramphenicol include typhoid, paratyphoid, dysentery, diphtheria, malaria and rickettsioses.

In addition to the above indications, Chloromycetin can also be used as a reserve antibiotic in meningitis caused by pneumococci or Haemophilus influenzae due to its good liquid circulation.

Chloramphenicol is used topically for the treatment of conjunctivitis (conjunctivitis) and for the treatment of corneal infections. Chloromycetin is also used for blepharitis (inflammation of the eyelids). It is also used for skin infections and eczema.

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Risks and side effects

The most serious side effect of chloramphenicol is the so-called aplastic anemia. It rarely occurs, but it is life threatening. Aplastic anemia damages the bone marrow, which means that almost no blood cells are produced in the bone marrow. Aplastic anemia can also occur weeks and months after treatment with Chloromycetin. Signs of this anemia include extreme fatigue, bleeding, and possibly serious infections.

It should be noted that chloramphenicol interacts with blood thinners, methotrexate and sulfonylureas. This results in increased efficiency. Barbiturates and phenytoin cause reduced efficacy of Chloromycetin. When taking oral contraceptives (for example the "baby pill"), make sure that chloramphenicol affects the effectiveness of the preparation. It should therefore also be prevented.

Chloromycetin is contraindicated in newborns. There are also contraindications for severe liver failure, pregnancy and breastfeeding.

Preparations containing chloramphenicol require a prescription. Chloromycetin should not be used in food-producing animals in the EU.

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