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Article about Levaquin

Levofloxacin is an antibiotic which first appeared on the market in Japan in 1992, as well as in Europe and the United States in the following years. The substance achieves its effect by inhibiting the enzyme gyrase, which comes from infectious bacteria. Levaquin is used in preparations to fight against bacterial infections of the gastrointestinal tract, respiratory tract and ears, nose and throat.

What is levofloxacin?

The active ingredient Levaquin is assigned to the fluoroquinolones group, which also includes the closely related active ingredient, ofloxacin. Moxifloxacin and ciprofloxacin are also part of this group of antibiotics.

Levofloxacin was first approved in Japan in 1992. Other approvals were granted in 1996 in the United States and then in Germany (1998). Levaquin is used as an antibiotic to treat bacterial infections affecting the gastrointestinal tract, the prostate, the respiratory tract or the ears, nose, and throat.

The drug achieves its effectiveness by inhibiting the enzyme gyrase, which comes from the DNA of infectious bacteria. Levofloxacin is described in chemistry with the empirical formula C 18 - H 20 - F - N 3 - O 4 and has a moral mass of 361.37 g / mol. The slightly yellowish powder is usually given as a film-coated tablet and taken orally. It is also available as an infusion solution.

Pharmacological effects

The mechanism of action of Levaquin is bactericidal. This means that the drug kills bacteria. The pharmacological effect on the targeted bacteria is typical for representatives of fluoroquinolones by inhibiting the enzyme gyrase. This inhibits the spatial orientation of DNA molecules and is of paramount importance for the viability of a bacterium, as it is responsible for the so-called DNA supercoiling of a bacteria.

The medical literature reports that levofloxacin is particularly effective against the bacteria Moraxella catarrhalis and Haemophilus influenzae, a trigger for various respiratory infections. Chlamydia and pneumococci are also very sensitive to Levaquin, so the pharmacological effect is extremely high.

Long-term intake of levofloxacin should be avoided, if possible, as the active ingredient can also tire human organs in the long term.

Medical application and use

Levaquin is treated in a broad spectrum and with reserve antibiotics. It is prescribed to treat mild to moderate bacterial infections in adults that are caused by bacteria sensitive to levofloxacin. These include a .: complicated urinary tract infections, inflammation of the respiratory tract such as bronchitis or pneumonia (pneumonia), inflammation of the nasal sinuses (acute bacterial sinusitis), infections of the skin and subcutaneous tissue (soft tissue) , including the muscles, and ultimately also prolonged infections of the prostate (prostate gland).

The scope of Levaquin therefore largely corresponds to that of the closely related active ingredient of loxacin. The applicability to inflammation of the lungs (pneumonia) results from the fact that the drug levofloxacin has a higher antibacterial effect than ofloxacin.

Levaquin is usually given as a film-coated tablet and taken by mouth. Treatment with a solution for infusion may also be advised, especially in the case of more serious illnesses.

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    Risks and side effects

    Like all antibiotics, levofloxacin can cause side effects. However, these do not occur with all treatments. Before taking it for the first time, check for intolerance. In this case, Levaquin should not be administered. This is also the case if you are allergic to other quinolo antibiotics (for example ofloxacin, moxifloxacin or ciprofloxacin), if you suffer from epilepsy and if you have been treated with quinolo antibiotics, tendon complications have already occurred (eg Tendinitis), pregnancy is known or breastfeeding. Children and adolescents are generally not treated either.

    In medical studies, the following undesirable side effects have been associated with treatment with levofloxacin:

    Uncommon (may affect up to 1 in 100 people): itching and rash, upset stomach or indigestion, loss of appetite, general weakness, change in the number of white blood cells, headache, nervousness, sleep disturbance, dizziness and drowsiness.
  • Rare (affects less than 1 in 1,000 people): tingling in the hands and feet without adequate external causes (paraesthesia), tremors, anxiety, restlessness and stress, depression, increased heart rate, breathing problems or wheezing (bronchospasm) or shortness of breath (dyspnea).
  • Very rare (affects less than 1 in 10,000 people): low blood sugar (hypoglycemia), hearing or vision problems, increased sensitivity to light, Smell and taste disturbances, circulatory arrest, fever, and persistent feeling of sickness.

    Blog:

    1. Addition of levofloxacin to standard treatment for staphylococcal bacteremia
    2. Community acquired pneumonia moxifloxacin a prospective randomized
    3. Fda approves first generic us versions of levofloxacin
    4. Fda recommends levofloxacin for the treatment of complicated and uncomplicated
    5. Pneumococcal resistance to levofloxacin has been identified
    6. Safety and efficacy of tigecycline compared to levofloxacin in the
    7. Short antibiotic therapy for legionary pneumonia
    8. The case of the development of acute rhabdomyolysis in the context
    9. The effectiveness of the 7 day course of furazolidone levofloxacin
    10. Triple eradication regimen containing levofloxacin vs quadrotherapy
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