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Article about Keflex

The active pharmacological ingredient Cephalexin is an antibiotic used to treat bacterial infections. Keflex can be administered orally and belongs to the antibiotic group of cephalosporins.

What is Cephalexin?

As a cephalosporin, Keflex is one of the so-called beta-lactams, which are produced semi-synthetically on an industrial scale. It is a prescription antibiotic in Germany. After taking a tablet with the active ingredient Cephalexin, absorption is rapid via the mucous membranes of the gastrointestinal tract.

The half-life in the blood is approximately 1 hour. Although Keflex also circulates through liver cells, it is not broken down or changed in its chemical structure like many other antibiotics. At the end of the half-life in blood plasma, Cephalexin is therefore completely excreted and not metabolized in the urine via the two kidneys.

The molecular weight of the Keflex antibiotic is approximately 348 g / mol. Cephalexin multipeptide consists of the chemical elements carbon, hydrogen, nitrogen, oxygen and sulfur.

Pharmacological effects

The antibiotic is used against germs sensitive to Keflex. As a so-called broad spectrum antibiotic, Cephalexin acts against a large number of bacterial pathogens. An effect on viruses is excluded.

After oral administration, the active ingredient is rapidly distributed to all organs and tissues via the blood vessel system, the effect of the antibiotic is therefore systemic.

Keflex intervenes selectively directly in the multiplication of pathological bacteria by depositing in the cell wall. This results in an inhibition of the synthesis of the cell wall of these bacteria which can no longer divide independently and therefore die. Because the cell wall of pathogenic bacteria must be intact for the metabolism of these pathogens to function properly.

Cephalexin blocks the synthesis of peptidoglycan after its storage in the cell wall of bacteria, but this low molecular weight protein body is determining for the stability of the cell wall of bacteria. The antibiotic Keflex therefore guarantees that the structural integrity of the bacterial cell wall can no longer be achieved. The immediate consequence is the death of the bacteria in infected areas of the body. Cephalexin acts by its direct intervention in the metabolism of pathogenic bacteria.

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Medical application and use

In medical applications, the broad spectrum antibiotic Keflex is particularly effective against so-called gram-positive bacteria. These bacterial strains include, for example, staphylococci, streptococci, coli bacteria or tights.

As a special feature, Cephalexin has an enterococcal lacuna which must be observed during treatment. Keflex is therefore not explicitly effective against enterococci, because the chemical composition of their cell wall is very different from other Gram-positive germs.

The effect of Cephalexin only affects bacteria. It has been repeatedly proven that Keflex has no effect against mycoplasma, chlamydia or multi-drug resistant bacteria (MRSA).

The main areas of application of oral Cephalexin treatment are bacterial infections of the upper respiratory tract, such as tonsillitis or laryngitis. Bacterial pneumonia also responds well to treatment with Keflex as long as the active ingredient can be administered orally.

Administration of the active substance Cephalexin by infusion is contraindicated. Other typical areas of application are bacterial otitis media, urinary tract infections caused by gram-positive bacteria and bacterial skin infections.

Bases of infection in soft tissues and bones that are deeper in the body can also be treated with Keflex. Therefore, chronic bone inflammation, osteomyelitis, joint inflammation or phlegmon can also be treated with the active ingredient.

Cephalexin diffuses into body tissues through the bloodstream and can therefore kill pathogenic germs on site, even in the case of chronic progression. In the case of these non-acute infections, however, particular attention should be paid to the duration of treatment and the dose so as not to compromise the success of treatment and to effectively prevent resistance.

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Risks and side effects

As with many other antibiotics, resistance can develop through the administration of Keflex. The antibiotic would then no longer work. To prevent bacteria from becoming resistant, if prescribed, Cephalexin should always be taken for a sufficiently long time and at an appropriate dose, calculated according to body weight.

In case of known hypersensitivity reactions to Keflex, the active substance should not be used. Adverse body reactions and side effects may occur, especially at the start of treatment. Most of the side effects of Cephalexin relate to gastrointestinal complaints with symptoms such as nausea, vomiting or diarrhea. The doctor must decide in each case whether such a drug should be stopped.

Other known side effects include dizziness and an electrolyte imbalance. Cross resistance can also occur when penicillin is given at the same time. The presence of Keflex in the urine may temporarily distort the diagnostic values in urine tests.

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