Buy Ilosone Online

The description

Biconvex, coated, white tablets.

Directions for use

Mild to moderate infectious and inflammatory diseases caused by microorganisms sensitive to erythromycin, including diphtheria, whooping cough, trachoma, brucellosis, legionnaires' disease, scarlet fever, otitis media, cholecystitis, gonorrhea, syphilis, respiratory tract infections of community origin (pharyngitis, tonsillitis, bronchitis, bronchopneumonia, SARS). Treatment of infectious and inflammatory diseases caused by pathogens resistant to penicillin, tetracyclines, chloramphenicol, streptomycin.

Cons-indications

Erythromycin is contraindicated in case of hypersensitivity to this antibiotic, when taking terfenadine, astemizole, colchicine or cisapride, pimozide. Ilosone is contraindicated in cases of jaundice in the anamnesis, expressed violations of the liver, during breastfeeding, in children under 3 years of age.

Dosage and administration

Accepted 1 hour before a meal or 2-3 hours after a meal with water! If the effect of the drug is unusual, you should immediately consult a doctor!

The children: Generally apply 30 mg / kg to 50 mg / kg body weight per day, divided into 2 to 4 doses, or every 6 to 12 hours. In severe infections, the dose can be doubled and applied every 6 hours. It is used only for children in which a single dose is at least one tablet (the tablets cannot be divided!). If there are swallowing problems, other forms (eg syrup) should be used. The maximum daily dose is 4 g.

Adults: Usually apply from 1 g to 2 g per day, divided into 2 to 4 doses. In severe infections, the dose can be increased to 4 g per day, divided into several doses.

Treatment of primary syphilis: as prescribed by your doctor.

Gonorrhea infections: treatment begins parenterally, then 250 mg every 6 hours for 7 days.

Legionnaires' disease: in moderate severity in adults - 500 mg orally 4 times a day for 14 days.

Impaired liver function. It is advisable to take the concentration of the drug in the serum under control.

Impaired kidney function. A dose change is not necessary.

Elderly patients. No dosage change required. Caution is advised in case of frequent dysfunction of the liver or bile ducts.

The duration of treatment depends on the severity and type of infection.

Ilosone should be used for at least 2-3 days after the symptoms disappear. For infections caused by group A streptococci - at least 10 days. If the medicine has not been taken at the scheduled time, you should take the next dose as soon as possible, then continue taking the medicine regularly on time. Do not take a double dose to make up for the lack.

Side effect

From the digestive system: nausea, vomiting, epigastric pain, cholestatic jaundice, tenesmus, diarrhea, dysbiosis, rarely - pseudomembranous enterocolitis, impaired liver function, increased activity of hepatic transaminases, pancreatitis.

Allergic reactions: rash, hives, eosinophilia; rarely - anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis, interstitial nephritis, rare cases of pancreatitis and seizures.

Effects due to chemotherapeutic action: oral candidiasis, vaginal candidiasis. Cases of pseudomembranous colitis during or after antibiotic therapy are described.

From the sensory organs: reversible ototoxicity - hearing loss and / or tinnitus (when using high doses - more than 4 g / day).

On the side of the cardiovascular system: rarely - tachycardia, prolongation of the QT interval, flickering and / or atrial flutter (in patients with an initially prolonged QT interval).

In the event of any of the above events or other undesirable adverse events, it is necessary to inform the doctor.

Overdose

Symptoms: with acute intoxication, the appearance of nausea, vomiting, abdominal pain is characteristic. In case of chronic overdose, a violation of liver function (jaundice, hepatitis) develops, up to acute liver failure, often accompanied by fever, leukocytosis, eosinophilia. Allergic skin reactions, anaphylactic shock and, in rare cases, cholestatic hepatitis and even temporary hearing loss, especially in patients with kidney failure, may be observed.

Treatment: urgent gastric lavage with activated charcoal (monitor the patient's condition to avoid aspiration!), Careful monitoring of the state of the respiratory system (if necessary, mechanical ventilation). Gastric lavage is effective even when taking a dose five times the therapeutic average. With the development of anaphylactic conditions - adrenaline, antihistamines, corticosteroids.

If symptoms of overdose occur, see a doctor immediately!

Interaction with other drugs

Serious side effects have been reported in patients taking erythromycin in combination with colchicine, simvastatin, lovastatin, atorvastatin and calcium channel blockers metabolized with CYP3A4 (verapamil, amlodipine, diltiazem). The interaction of erythromycin and colchicine is life-threatening and can occur while using both drugs at the recommended doses. Rhabdomyolysis with possible renal failure may develop in critically ill patients receiving lovastatin concomitantly with erythromycin. Creatine kinase (CC) and serum transaminase levels should be closely monitored in patients receiving both lovastatin and erythromycin.

With the simultaneous use of erythromycin with theophylline, aminophylline, caffeine, cyclosporine, as well as carbamazepine, valproic acid, hexobarbital, phenytoin, alfentanil, disopyramide, bromocriptine, the risk of developing a toxic effect increases.

With the simultaneous administration of terfenadine or astemizole, the development of an arrhythmia is possible (fibrillation and ventricular flutter, ventricular tachycardia, until death); with dihydroergotamine or non-hydrogenated ergot alkaloids, vasoconstriction to spasm, dysesthesia is possible.

Erythromycin can improve the pharmacological effects of benzodiazepines, improve the effect of anticoagulants with methylprednisolone, felodipine and coumarin, and reduce the effectiveness of hormonal contraception.

Ilosone increases the effect of sildenafil, digoxin. If concomitant erythromycin is used, the dose of sildenafil should be reduced. Drugs that block tubular secretion prolong the action of erythromycin.

Incompatible with lincomycin, clindamycin and chloramphenicol (antagonism). Erythromycin reduces the bactericidal effect of β-lactam antibiotics (penicillins, cephalosporins, carbapenems).

Application features

Pregnancy and breast feeding. The drug can only be prescribed to pregnant women if absolutely necessary (if the expected benefit to the mother outweighs the potential risk to the fetus).

Ilosone passes into breast milk, so women should not breastfeed.

Influence on the ability to drive and maintain mechanical devices. There are no data on the effect of the medicine on the ability to drive and maintain mechanical devices.

Safety precautions

Hepatotoxicity

Impairment of liver function is possible with increased levels of hepatic aminotransferase and the development of hepatitis with or without jaundice.

QT interval extension

Erythromycin can cause a prolonged QT interval and rare cases of arrhythmias. Cases of torsade de pointes ventricular arrhythmias in patients receiving erythromycin are described. The use of erythromycin should be avoided with an increase in the QT interval, in patients at high risk of developing arrhythmias (with proarrhythmic risk factors: hypokalaemia or hypomagnesemia uncorrectable, clinically significant bradycardia), as well as patients receiving anti-arrhythmics class IA (quinidine, procainamide) or class III (dofetilide, amiodarone, sotalol). In elderly patients, the sensitivity to QT prolongation is higher.

Syphilis during pregnancy

Taking erythromycin during pregnancy does not prevent the development of congenital syphilis. After birth, children should receive appropriate penicillin treatment.

Diarrhea associated with Clostridium difficile

The development of diarrhea can vary in severity, from mild diarrhea to fatal colitis. This infection may be resistant to antibiotic therapy and may require the removal of part of the intestine. If Clostridium difficile is suspected or confirmed to be the cause of the diarrhea, antibiotic therapy should be stopped immediately. Treatment of diarrhea should include correction of the water-electrolyte balance, parenteral nutrition, the use of metronidazole and vancomycin, in some cases, surgical treatment.

Due to the presence of lactose in the preparation, it is not recommended for patients with congenital galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption.

With erythromycin, hepatotoxic drugs are not recommended.

Do not drink alcohol while taking erythromycin.

Ilosone and its derivatives, when taking hormonal contraceptives, may reduce their effect. Therefore, it is recommended to apply in addition to non-hormonal contraceptive methods.

Erythromycin can increase the symptoms of myasthenia gravis.

Use with caution in children under 6 years of age, who may have difficulty swallowing.

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