The comparative effectiveness of the five modes of antimicrobial acne treatment
Acne vulgaris (acne vulgaris) is a fairly common medical problem, despite a large number of acne treatment methods and the availability of effective drugs.
In a randomized controlled trial, a comparative evaluation of the effectiveness of 5 modes of antibacterial treatment of mild to moderate acne was carried out. The study involved 649 patients with facial acne. A microbiological study undertaken before the treatment revealed in 96 to 99% of the patients a colonization of the facial skin Propionibacteria acnes, resistant to erythromycin at 44 to 48%, to clindamycin at 38 to 45% and tetracycline in 12 to 27% of cases. The evaluation of the efficacy of the treatment was carried out after 18 weeks.
According to the data obtained, all the modes studied were equivalent in efficiency.
When analyzing the clinical results, it was noted that the effectiveness of tetracycline treatment decreased with the colonization of patients by P.acnes strains resistant to this drug. A study of the economic effectiveness of the therapy showed that benzoyl peroxide had the greatest effectiveness of the drugs studied, minocycline - the smallest.
Thus, despite the fact that all of the modes studied have shown almost the same clinical efficacy, local therapy with benzoyl peroxide is more preferable, since it has the greatest economic efficiency and does not affect the occurrence of resistance to antibiotics from the microflora of the face.