The synthetic peptide D2A21, which has antimicrobial properties, inhibits the growth of Pseudomonas aeruginosa in rats with infected burns, which results in a significant increase in survival. These data were published in the April issue of Plastic and Reconstructive Surgery.

Researchers at the Southern Illinois University School of Medicine in the city of Springfield (USA, Illinois) have infected burns in P.aeruginosa laboratory rats. Three hours later, the wounds were treated with the antimicrobial peptide D2A21 (Demegel; Demegen, Inc.) or an ordinary gel that did not contain an antimicrobial preparation. Wound healing was then continued daily. Butofanol has been administered to animals to stop the pain syndrome. On the burn, the placebo animals showed an increase of more than 100,000 CFU / g of tissue on days 2 and 3, while the animals whose wounds were treated with an antimicrobial peptide remained sterile. Both groups of animals showed growth of P.aeruginosa in muscle tissue under the scabies, but the concentration of microorganisms was significantly lower in animals whose wounds were treated with D2A21.

Even if the animals treated with the antimicrobial peptide were infected with P.aeruginosa, 6 rats out of 7 survived, while all the animals in the control group died on average within 8 days.

Researchers believe the data obtained is of great clinical importance in the additional treatment of burns or infectious processes using local antimicrobial agents.