High efficacy of moxifloxacin in preventing bacteremia after tooth extraction

The efficacy of oral antibiotic prophylaxis with amoxicillin, clindamycin and moxifloxacin in preventing bacteremia after tooth extraction is compared. The study involved 221 adult patients. All patients have been shown to have tooth extraction under general anesthesia. The patients were randomly assigned to the control group, the amoxicillin, clindamycin or moxifloxacin group (the drugs were prescribed at a dose of 2 g, 600 mg and 400 mg, respectively, 1 to 2 hours before induction of l 'anesthesia). Venous blood samples were taken from each patient before the procedure, 30 seconds, 15 minutes and 1 hour after tooth extraction. Blood was collected in BACTEC Plus aerobic and anaerobic blood vials and incubated in a BACTEC 9240 machine. The cultures were isolated and identified using traditional technique.

The frequency of bacteremia in the control group, the amoxicillin, clindamycin and moxifloxacin groups was 96, 46, 85 and 57%, respectively, for 30 seconds; 64, 11, 70 and 24%, respectively, for 15 minutes; and 20, 4, 22 and 7%, respectively, after 1 h. The most frequently isolated microorganisms in all groups were representatives of the genus Streptococcus (44-68%), with the lowest frequency of excretion (44%) was noted in the group amoxicillin. Prophylactic use of amoxicillin and moxifloxacin has been shown to be very effective, reducing the frequency and duration of bacteremia after tooth extraction. Prophylactic use of clindamycin has been shown to be ineffective.

Thus, the prophylactic use of moxifloxacin to prevent bacteremia after tooth extraction is an excellent alternative if it is not possible to prescribe a beta-lactam antibiotic to the patient.